Results for “from the comments”
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Me-Too Two

Yesterday I introduced the gold-mine model.  Today, I want to look at some solutions but also ask whether the model fits the pharmaceutical market.

Recall, the problem is that I discover a gold-mine, you undermine my profits by digging on nearby land.  Society loses because instead of searching for another gold-mine you spend resources trying to exploit what has already been discovered.  Applied to me-too drugs the idea is that firm A innovates and earns big profits, firms B,C,D try to imitate and grab some of the profits rather than search for innovations of their own. 

In the gold-mine model one solution is to give the miner who first makes the discovery the mining rights on all nearby land.  The miner won’t exploit these rights but will prevent others from wasting resources through undermining.  How does this apply to me-too drugs?  Critics of the pharmaceutical
industry will probably be upset to find that the analogous solution is to grant stronger patent rights.  In particular, the problem with me-too drugs is companies investing resources in R&D that will end up producing a drug with similar effects through somewhat different means.  If patent rights were broader then the costs of undermining would be higher and the me-too problem reduced.

Thus, me-too policy is patent policy and now we begin to see why the problem is complex.  Broader patents, for example, have costs as well as benefits.  Selden’s auto patent, for example, was originally held to be so broad that it almost finished Henry Ford.  (For more examples see my paper Patent Theory versus Patent Law (email me if you can’t get access) or the new book Innovation and Its Discontents.)

Moreover, we have been assuming that the innovating firm strikes gold and then other firms rush onto nearby land.  But that’s not the way most pharmaceutical innovation works.  More often, there is some basic research, often done in a university lab, which suggests a possible drug target or mechanism.  The research is public knowledge so a number of pharmaceutical firms begin the long slog of trying to turn an idea into a drug.  Think of the original research as a prospector shouting "there’s gold in them thar hills," – the firms then rush into the hills to start researching/digging.  One of them may strike gold first but the others are close behind.

The key point is that the R&D used to develop the me-too drugs was not spent to undermine the innovator it was spent in an effort to become the innovator.  Think about it this way.  Ten people are in a race to deliver a letter.  Critics of me-too drugs complain that the runner coming in second is wasting society’s
time.

Now it is possible to have too many firms racing to be the innovator – perhaps we should only have 8 firms in the race not 10.  But critics of me-too drugs don’t argue that there is too much R&D, which at least would be consistent, they argue that there is too little. 

Although it is possible to have too much R&D, I find the argument especially difficult to believe in the pharmaceutical industry.  First, even in the best scenario the returns to the innovating firm are less than the social returns so "too much" R&D may simply make up for this defect.  Second, there are many positive externalities to drug research.  A substantial fraction of the increase in life expectancy over the past thirty years has been due to pharmaceuticals and the value of this reduction in mortality is in the trillions.  Third, research indicates that the R&D efforts of different firms is in fact complementary – when you drain your mine of water my costs of mining fall.   

Tomorrow I will wrap up with some final comments, Why me-too for you may not be me-too for me.

Nature and Nurture Again

I want to comment on a common error in the discussion of my post Nature, Nuture, and Income.  (See for example the comments at Jane Galt, Kevin Drum and also the trackbacks).

Despite my warning, many people thought that graph was saying something important about the average income of adoptees versus that of biological children.  Hence many people argued that "the results" were explained by discrimination against Korean Americans, poor nutrition of the adoptees before being adopted, or low IQ of children given up for adoption.

For the record, Asian Americans in general and the children in this sample have higher income and more education than the average American.  More fundamentally, however, these comments have misunderstood what is to be explained.  It is true that the average income of the adoptees was lower than that of biological children but the adoptees are also younger.  Once you control for this and a few similar factors the mean income difference goes away (think of shifting the adoptee line up).  What remains, and this is the key point, is that the biological line is upward sloping and the adoptee line is flat.

What my post and the paper are all about is the difference in the slope of the two lines, i.e. why is it that child income increases with parental income for biological children but not for adopted children.

Addendum: Suppose we control for age and other factors which in effect will raise the adoptee line then we could phrase the results as ‘adoptees do better than biological children raised in poor households but worse than biological children raised in rich households.’  The explanation is simple from the genetic point of view – adoptees are drawn more or less randomly while high income parents tend to pass on high-income genes and low income parents tend to pass on low-income genes.  It’s going to be very difficult, however, to explain why poor parents treat their adopted children better than their biological children but rich parents treat their adopted children worse.

Nature, Nurture and Income

Some might suggest that parents treat their biological and adopted children differently and this is what accounts for the difference in incomes.  The interpretation is very uncharitable to the parents who have volunteered to raise an adopted child and I think it implausible.  Moreover, unless every adopted child is treated equally poorly in all families, then we would still expect the income of adoptees to increase with parental income but perhaps starting at a lower level.

The other proviso is that the Holt experiment is only informative for the experimental variation in environment.  In other words, we can tell from the Holt experiment that variation in parental income from around 25 thousand to 175 thousand doen’t have much impact on variation in adopted child income but all these children are raised in the United States so culture and other variables are roughly similar.  In other words, move a child from a poor country to a rich country and you would expect a much bigger treatment effect than moving a child from a poor family to a rich family. 

How about a flat tax?

In 1940 the instructions to the Form 1040 were about four pages. Today they are more than 100 pages, and the form itself contains more than 10 schedules and more than 20 worksheets. The complete tax code totals about 2.8 million words – about four times longer than "War and Peace" (and considerably harder to parse).

That is from a New York Times Op-Ed.  And Andrew Sullivan has been pushing for a flat tax. 

My comments:

1. In a sufficiently wealthy or sufficiently egalitarian society, a flat tax is a no-brainer.  Distributional dilemmas are the main obstacle, whether in reality or the public perception.

2. Much of the complexity of the U.S. tax system stems from the definition of income; the simplification benefits from moving to a single flat rate, while real, are often overrated.  A VAT can be complex as well.

3. If I were spending political capital on reforming a tax system, I would sooner push for a more favorable treatment of capital income.  Similarly, if we were sacrificing revenue or fairness, my priority would again point toward capital income.

The bottom line: My ideal tax system has two or three rates, with slight progressivity.  I would keep the tax privileges of non-profits, but otherwise be reluctant to use the tax system for social engineering.  So I favor a "not quite flat tax."  Tax simplification is worth doing, whether or not it is linked to pure flatness of rates.  That being said, flat tax advocacy remains a good way to hold politicians’ feet to the fire.  All tax systems are too complicated, and moves toward simplification are rarely a mistake.

Addendum: Bruce Bartlett summarizes some tax reform ideas.

Organ Transplants

Bob Hickey, who lives near Vail, had needed a transplant since 1999 because of kidney disease. He met donor Rob Smitty of Chattanooga, Tenn., through Matching Donors.com, a for-profit Web site created in January to match donors and patients for a fee.

On Wed. the transplant was performed. It is the first “publicly brokered” transplant to occur in the United States. It is currently illegal to pay donors so Rob Smitty, the donor, was not paid (Hickey did cover Smitty’s expenses). Hickey did pay to have his name listed by MatchingDonors.com and this has upset a lot of people. No one seems upset, however, by the fact that the Hickey’s doctors were paid, his nurses were paid, the hospital was paid etc.

See my article for more on organ donation. Kieran Healy at Crooked Timber comments on the definition of death and another organ donation case in the recent news.

Thanks to Taggert Brooks for the link.

More on Vaccines

Though Alex has already blogged about the Kremer/Snyder paper on vaccines versus cures, there are, I think, a couple of comments worth adding.

According to Kremer and Snyder, monopoly sellers would rather sell cures than vaccines. To get this result, they need some heterogeneity: we all have different probabilities of getting sick (though we all find it equally costly to get sick).

But what if you introduce the opposite kind of heterogeneity? (That is, we all have different costs of getting sick, even though we all face the same probability of getting sick.) Then it’s a nice little exercise for your students to show that the cure and the vaccine are equally lucrative monopolies (ignoring the positive externalities of the vaccine).

A more important observation: In the Kremer/Snyder setup (still ignoring positive externalities), it’s a good thing for sellers to invest in cures rather than vaccines. The reason cures are more profitable is that they in essence allow perfect price discrimination. So with cures, there’s no deadweight loss due to monopoly; with vaccines there is.

The analysis changes if you assume, say, that a vaccine prevents a four-day illness, but a cure only cuts two days off your illness. Then vaccines might or might not be socially preferable to cures—but in that case, willingness-to-pay for vaccines versus cures would double. This gives sellers an incentive to produce vaccines. The incentive isn’t perfect, but it goes in the right direction.

The Microeconomics of Social Security Privatization

Social security privatization has a little-discussed benefit, done properly it is equivalent to a cut in marginal tax rates. A problem with the current system is that there is little relationship on the margin between taxes paid and benefits received. On average, of course, those who pay more taxes get more benefits (although not proportionately there is a subsidy to low-earners). But because the rules are complex and based on average earnings over a long period of time there is little connection between your social security taxes on an additional hour of work and your social security benefits for that additional hour.

To see why this is important consider the difference between social security and an IRA. If a worker works an additional hour, earns $10 and puts $1 into the IRA he knows the $1 will produce a benefit 30 years down the line when he retires. The $1 contribution to the IRA is not a tax, it’s consumption, a benefit of working extra hours. On the other hand if a worker earns $10 and $1 is taken and paid into social security there is no clear connection to retirement benefits. Social security payments, therefore, are taxes – and like other taxes they deter work effort and create a dead weight loss.

Privatizing social security, or in some other way creating personal accounts, would reestablish a link between marginal payments and marginal benefits and thus would be equivalent to a cut in tax rates.

The insight goes back to my colleague Jim Buchanan and his 1968 paper “Social Insurance in a Growing Economy: A Proposal for Radical Reform.” National Tax Journal, Vol. 21 (December 1968): 386-95

See also Tyler, Arnold Kling, Victor Davis and Brad DeLong who have been discussing the political issues of social security privatization.

Kydland and Prescott: New Nobel Laureates

This year’s Nobel Prize in economics went to Finn Kydland and Edward Prescott . Kydland and Prescott wrote a famous 1977 piece (Journal of Political Economy) on time inconsistency. Ever wonder why government policy toward prescription drugs is so problematic? Kydland and Prescott had the answer. The optimal policy will first award the drugmakers a patent and allow them to charge a high price. But once the drug is developed, the “rents” will be confiscated. Optimal policy will revoke the patent and lower the price. After all, once you have the drug. why not let everybody have it cheaply? Of course the drugmakers are aware of this danger in advance, and they are correspondingly reluctant to develop new drugs. Alex posted on this logic just days ago.

In more formal language, the optimal policy is not a time consistent policy. This develops earlier ideas from Thomas Schelling on game theory. Schelling’s point was that nuclear deterrence can fail because, once destruction is aimed your way, you don’t necessarily wish to retaliate.

The logic of time consistency is quite general. It applies to regulatory policy issues, tax policy, monetary policy, foreign policy (threaten Saddam, but do you really want to have go to through with it?), and strategic behavior in a wide variety of settings.

Here are my earlier comments on Prescott, which link to other facets of his work. He arguably has enough contributions to win the prize twice. Kydland is less well known but is an important figure nonetheless. And it doesn’t hurt that he is Scandinavian (Norwegian).

Are the pair deserving? Absolutely yes.

Why did they win this year? I’m guessing that in the midst of a partisan U.S. election, the Swedes did not want to pick Paul Krugman or Robert Barro (pro-Bush), for fearing of appearing too political. Note that the economics prize has stood under criticism for some time now, for not being “scientific” enough.

And this pick the betting market got right. Prescott had opened up a clear lead in the betting market some time ago.

Nobel Prize update

Here is new information from the betting market. Ed Prescott has opened up a lead (then Barro, then Krugman), and Thomas Schelling has joined the list. Read my previous comments; the winner will be announced Monday.

As for tomorrow’s literature prize, John Updike, Margaret Atwood, and Philip Roth are the leaders.

Update: Here is the dark horse who won the literature prize, I am not a big fan.

More on what Prediction Markets Mean

Michael’s post on Charles Manski’s paper challenging prediction markets has been widely discussed. Manski’s paper is difficult and a number of people wrote asking me for further explanation. Luckily, Daniel Davies has done some of the heavy lifting. Michael also offers further comments here.

My take: Manski shows that the market price is not, for example, the mean subjective belief of the market participants. But who said it was? The argument of prediction market proponents is that the market price is a good, perhaps the best, predictor of the future event. Manski does not challenge this argument. In particular, Manski does not show (or try to show) that there is an alternative way of aggregating individual information that results in better predictions. In this sense, I think the Manski paper is something of a red herring.

I would not claim, however, that information markets cannot be improved. Movements in the price of oil tell us something about trouble in the Middle East. But the oil market was not designed to elicit information about the Middle East. The information in markets is an accidental byproduct of trading. It would be a real surprise if the rules that make for good oil trading are the same rules that make for good prediction of events in the Middle East. Sundering information markets from trading markets, therefore, is a big advance and one that is likely to lead to better market design for information revelation, perhaps with help from papers like Manski’s (contra Daniel, who argues that to work well information markets must be tied to trading markets).

Addendum: Victor, a former student of Manski’s, at the Dead Parrots Society adds considerable wisdom to the discussion.

Jeffersonians vs Hamiltonians

Entering Monticello,Thomas Jefferson’s home, you are flanked by two busts, Jefferson on one side and Alexander Hamilton on the other. Since the two were political foes it’s a surprising choice. But the busts were placed there by Jefferson himself who said, “we were ever-opposed in life and now we shall be ever-opposed in death.” The Jefferson-Hamilton battle continues to this day (read the link for more and don’t miss the many interesting comments.)

JeffersonHamilton

Addendum: Brad was perhaps fooled by the name of this blog but then there are two of us.

The dangers of IQ

By the title alone you know that IQ and the Wealth of Nations is going to be a controversial book. The book was recently reviewed, largely negatively but on scientific grounds without any charges of racism, in the Journal of Economic Literature (subs. required). What I didn’t know was that one of the authors, Professor Tatu Vanhanen, is the father of Finnish Prime Minister Matti Vanhanen. The professor’s words, therefore, have become a lightning rod for opponents of Matti Vahanen. So much so that the Finnish police considered whether to launch a criminal investigation of Professor Vanhanen for his comments on IQ, race, and the wealth of nations in a magazine interview. In the end, the police concluded that the Professor did not incite “racial hatred,” nevertheless I find the episode rather chilling.

Addendum: Here are some brave economists on this issue. Thanks to Gene Expression and Randall Parker for the pointer.

A comment I would never make on MarginalRevolution

Read Matthew Yglesias on the Endangered Species Act:

Did the president really gut the Endangered Species Act yesterday while no one was paying attention? So I’ve heard, at any rate. If so, good riddance. You’ll all yell at me, I suppose, but really: Who cares? Species die, shit happens, get over it. Clean air, clean water, and lower carbon emissions I’ll get behind that stuff impacts, you know, people.

Here are my more moderate comments from some time ago.

I should link to Matt more often, we share a Best Buy, plus he doesn’t want to worry about Iranian nukes. But when it comes to Dick Gephardt, however…read this.

John Kerry’s hi-tech plan

Here is one summary of his latest proposals, the bracketed text is my comments:

Sen. John Kerry called Thursday for increased investment and support for America’s high-tech industry. His proposals include:

— Encouraging technological innovation by cutting some capital gains taxes and revising or eliminating regulations that affect competitiveness. [Good news]

— Using tax incentives to expand universal broadband access, which he believes will add $500 billion and 1.2 million new jobs to the economy. [ I don’t see the social benefit here, the private benefits of broadband are largely internalized; it sounds like this is based on a bad economic impact study.]

— Increasing government research funding in science and technology, including money for “pure” science research. [Government subsidies for science should be oriented toward the “pure” side of the spectrum. We need to lengthen our time horizon here, and let’s focus on infectious diseases and non-polluting energy sources. I am much more skeptical about the government’s ability to guide applied technology. Remember Synfuels? But if we are going to do this, we must make real spending cuts elsewhere, most of all in Medicare]

— Improving math and science education at the K-12 level and rewarding colleges for increasing the number of science and engineering degrees they award. [Sounds good, but I don’t expect federal involvement to bring a real improvement. Nor do I think the a marginal increase in science degrees will mean more scientific progress. How good is the marginal science student, and how much does he or she love science?]

The plan also involves spectrum auctions [good] and stem cell research [good].

The bottom line: This is better than I had expected. I do worry that only the worst and porkiest elements will survive the political process.