Results for “human challenge” 150 found
No one cared about Bryan’s spreadsheets
From Bryan:
The most painful part of writing The Case Against Education was calculating the return to education. I spent fifteen months working on the spreadsheets. I came up with the baseline case, did scores of “variations on a theme,” noticed a small mistake or blind alley, then started over. Several programmer friends advised me to learn a new programming language like Python to do everything automatically, but I’m 98% sure that would have taken even longer – and introduced numerous additional errors into the results. I did plenty of programming in my youth, and I know my limitations.
I took quality control very seriously. About half a dozen friends gave up whole days of their lives to sit next to me while I gave them a guided tour of the reasoning behind my number-crunching. Four years before the book’s publication, I publicly released the spreadsheets, and asked the world to “embarrass me now” by finding errors in my work. If memory serves, one EconLog reader did find a minor mistake. When the book finally came out, I published final versions of all the spreadsheets underlying the book’s return to education calculations. A one-to-one correspondence between what’s in the book and what I shared with the world. Full transparency.
Now guess what? Since the 2018 publication of The Case Against Education, precisely zero people have emailed me about those spreadsheets. The book enjoyed massive media attention. My results were ultra-contrarian: my preferred estimate of the Social Return to Education is negative for almost every demographic. I loudly used these results to call for massive cuts in education spending. Yet since the book’s publication, no one has bothered to challenge my math. Not publicly. Not privately. No one cared about my spreadsheets.
Here is more from Bryan Caplan. I would make a few points:
1. Work is hardly ever checked, unless a particular paper becomes politically focal in some kind of partisan dispute. You can take this as a sign that Bryan has not dented the political consensus so much, a point I think he would agree with.
2. Researchers discuss and consider your work in a particular area far, far more if you are an insider in that area, making the seminar circuit at top schools. To be clear, Bryan’s work is discussed far more by intelligent humans who are not education researchers, compared to what virtually all of the education researchers have produced. Bryan writes in internet space, where the barriers to entry are much lower. Good for him, I say (duh), but of course not everyone wishes to lower the entry barriers in this manner. And internet writing does have entry barriers of its own. For instance, Bryan has been blogging steadily for many years, which many researchers simply do not wish to do or maybe cannot do well at all.
3. Overall I think we are entering a world where “research” and “idea production” are increasingly separate endeavors. And the latter is moving to the internet, even when it is supplemented by non-internet crystallizations such as books. Bryan’s ideas, of course, have been germinating on EconLog for some time before his education book came out. Do you like this new world? What are its promises and dangers?
Yglesias on CRT
Matt Yglesias has an excellent post on schooling and politics emphasizing three points. First, there is a lot of diversity, equity, inclusion (DEI) nonsense which the schools are using to train teachers and administrators. Second, at the same time the school administrators/teacher’s unions are generally ignoring the very real cost to children and parents of the school closures, including the costs of a widening racial gap. Third, the schools are stigmatizing testing under the guise of promoting equity but in reality because the teacher’s unions know that when you test children you learn that not all teachers are equally capable.
[The DC Public Schools] also recommend that people read a bunch of Robin DiAngelo books and brag that “more than 2,000 DCPS staff have participated in Courageous Conversation training.” But is Courageous Conversation training a good idea? This NYT Magazine profile of the company and its founder made it sound pretty bad:
Singleton, who holds degrees from the University of Pennsylvania and Stanford, and who did stints in advertising and college admissions before founding what’s now known as Courageous Conversation in 1992, talks about white culture in similar ways. There is the myth of meritocracy. And valuing “written communication over other forms,” he told me, is “a hallmark of whiteness,” which leads to the denigration of Black children in school. Another “hallmark” is “scientific, linear thinking. Cause and effect.” He said, “There’s this whole group of people who are named the scientists. That’s where you get into this whole idea that if it’s not codified in scientific thought that it can’t be valid.” He spoke about how the ancient Egyptians had “ideas about how humanity works that never had that scientific-hypothesis construction” and so aren’t recognized. “This is a good way of dismissing people. And this,” he continued, shifting forward thousands of years, “is one of the challenges in the diversity-equity-inclusion space; folks keep asking for data. How do you quantify, in a way that is scientific — numbers and that kind of thing — what people feel when they’re feeling marginalized?” For Singleton, society’s primary intellectual values are bound up with this marginalization.
I don’t think Frankfurt School Marxists are going to take over society by injecting these ideas into K-12 schools or anything like that. What I so think is that time and money is being wasted on initiatives that are run by people who are somewhere between stupid and fraudulent.
And it’s important to take that seriously, not just because someone somewhere may take these goofy ideas seriously (see prior commentary about Tema Okun), but because fiscal tradeoffs are real. Dollars spent on DEI trainings that come with zero proof of efficacy are dollars that can’t be invested in things like D.C.’s successful teacher bonus pay program, updating school air conditioning, improving school lunches, reducing kids’ exposure to air pollution and lead poisoning, or any of the other various interventions that have decent evidence behind them.
Of course when I say that investing in higher quality school lunches is good for kids’ learning, what I mean is that it’s good as measured on standardized tests.
Standardized testing has become a weird discourse flashpoint, but I think everyone agrees that you can, in principle, assess someone’s competence in a given subject area with a test. And if you want to compare different people, you need to give them the same test. It’s only by making comparisons across classrooms and across time that we are able to persuasively demonstrate that particulates are bad for school performance, healthy meals are good for school performance, and air conditioning improves school performance in the summer.
All this would be uncontroversial, I think, except teachers’ unions don’t like the idea of assessing teachers based on their job performance.
Read the whole thing and subscribe to Slow Boring.
My Conversation with David Salle
I was honored to visit his home and painting studio, here is the audio, video, and transcript. Here is part of the CWT summary:
David joined Tyler to discuss the fifteen (or so) functions of good art, why it’s easier to write about money than art, what’s gone wrong with art criticism today, how to cultivate good taste, the reasons museum curators tend to be risk-averse, the effect of modern artistic training on contemporary art, the evolution of Cézanne, how the centrality of photography is changing fine art, what makes some artists’ retrospectives more compelling than others, the physical challenges of painting on a large scale, how artists view museums differently, how a painting goes wrong, where his paintings end up, what great collectors have in common, how artists collect art differently, why Frank O’Hara was so important to Alex Katz and himself, what he loves about the films of Preston Sturges, why The Sopranos is a model of artistic expression, how we should change intellectual property law for artists, the disappointing puritanism of the avant-garde, and more.
And excerpt:
COWEN: Yes, but just to be very concrete, let’s say someone asks you, “I want to take one actionable step tomorrow to learn more about art.” And they are a smart, highly educated person, but have not spent much time in the art world. What should they actually do other than look at art, on the reading level?
SALLE: On the reading level? Oh God, Tyler, that’s hard. I’ll have to think about it. I’ll have to come back with an answer in a few minutes. I’m not sure there’s anything concretely to do on the reading level. There probably is — just not coming to mind.
There’s Henry Geldzahler, who wrote a book very late in his life, at the end of his life. I can’t remember the title, but he addresses the problem of something which is almost a taboo — how do you acquire taste? — which is, in a sense, what we’re talking about. It’s something one can’t even speak about in polite society among art historians or art critics.
Taste is considered to be something not worth discussing. It’s simply, we’re all above that. Taste is, in a sense, something that has to do with Hallmark greeting cards — but it’s not true. Taste is what we have to work with. It’s a way of describing human experience.
Henry, who was the first curator of modern and contemporary art at the Metropolitan Museum in New York, was a wonderful guy and a wonderful raconteur. Henry basically answers your question: find ways, start collecting. “Okay, but I don’t have any money. How can I collect art?” You don’t have to collect great paintings. Just go to the flea market and buy a vase for 5 bucks. Bring it back to your room, live with it, and look at it.
Pretty soon, you’ll start to make distinctions about it. Eventually, if you’re really paying attention to your own reactions, you’ll use it up. You’ll give that to somebody else, and you’ll go back to the flea market, and you buy another, slightly better vase, and you bring that home and live with that. And so the process goes. That’s very real. It’s very concrete.
And:
COWEN: As you know, the 17th century in European painting is a quite special time. You have Velásquez, you have Rubens, you have Bruegel, much, much more. And there are so many talented painters today. Why can they not paint in that style anymore? Or can they? What stops them?
SALLE: Artists are trained in such a vastly different way than in the 17th, 18th, or even the 19th century. We didn’t have the training. We’re not trained in an apprentice guild situation where the apprenticeship starts very early in life, and people who exhibit talent in drawing or painting are moved on to the next level.
Today painters are trained in professional art schools. People reach school at the normal age — 18, 20, 22, something in grad school, and then they’re in a big hurry. If it’s something you can’t master or show proficiency in quickly, let’s just drop it and move on.
There are other reasons as well, cultural reasons. For many years or decades, painting in, let’s say, the style of Velásquez or even the style of Manet — what would have been the reason for it? What would have been the motivation for it, even assuming that one could do it? Modernism, from whenever we date it, from 1900 to 1990, was such a persuasive argument. It was such an inclusive and exciting and dynamic argument that what possibly could have been the reason to want to take a step back 200 years in history and paint like an earlier painter?
It is a bit slow at the very beginning, otherwise excellent throughout.
Average is over
Thirteen-year-olds saw unprecedented declines in both reading and math between 2012 and 2020, according to scores released this morning from the National Assessment of Educational Progress (NAEP). Consistent with several years of previous data, the results point to a clear and widening cleavage between America’s highest- and lowest-performing students and raise urgent questions about how to reverse prolonged academic stagnation.
The scores offer more discouraging evidence from NAEP, often referred to as “the Nation’s Report Card.” Various iterations of the exam, each tracking different subjects and age groups over several years, have now shown flat or falling numbers…
both reading and math results for nine-year-olds have made no headway; scores were flat for every ethnic and gender subgroup of younger children — with the exception of nine-year-old girls, who scored five points worse on math than they had in 2012. Their dip in performance produced a gender gap for the age group that did not exist on the test’s last iteration.
More ominous were the results for 13-year-olds, who experienced statistically significant drops of three and five points in reading and math, respectively. Compared with math performance in 2012, boys overall lost five points, and girls overall lost six points. Black students dropped eight points and Hispanic students four points; both decreases widened their score gap with white students, whose scores were statistically unchanged from 2012.
In keeping with previous NAEP releases, the scores also showed significant drops in performance among low-performing test-takers. Most disturbing: Declines among 13-year-olds scoring at the 10th percentile of reading mean that the group’s literacy performance is not significantly improved compared with 1971, when the test was first administered. In all other age/subject configurations, students placing at all levels of the achievement spectrum have gained ground over the last half-century.
Here is the full story, please note these are pre-Covid test scores, arguably now the problem could be worse. Via Luke, a concerned human.
My emails to Arnold Kling about the correct inflation model
After I cited low ten-year securities yields, Arnold asked for my basic model of inflation, here was my first email:
- Price level dynamics and money supply processes are murky, at least in recent times
- The median voter hates inflation
- The Fed won’t let inflation happen
…is my model.
I would add a dose of “inflationary pressures really do seem to be distributed pretty unevenly.”
End of email! Here was my second email to Arnold:
I think the Fed knows the true model in gross terms.
I also think there is a good chance the Fed will create a recession in limiting inflation.
But look at Japan. The EU. Even Italy. It’s not just the US.
Temporary inflation pressures all over the place, due to Covid and post-Covid adjustments. No fiscal financial crises. No long-term inflationary expectations of much note. Not in the developed nations.
The stock of saved wealth is now quite high relative to debt and deficits, especially if you count human capital.
So both the basic model and the markets predict no catastrophe, and also no run-away inflation. And central banks know how to boost the demand for money when needed.
Seigniorage returns from inflation are especially low in the contemporary environment, checking another motive for inflation. No “Assignats” revenue is in the works here.
I just don’t see what we’ve got “in the toolbox” to override all of that.
End of email! I should note that I agree with Summers that inflation is higher than it needs to be, that is bad, and it is because we overshot on our combined monetary/fiscal response.
I’ll also repeat my standard challenge: are you short the long bond? Are you buying those puts? I’m not so convinced if all you’ve got is “I’m not buying so many equities any more!”
Shame. Shame. Shame.
The Afghanistan war was an epic disaster. Nothing good came of it. The least we can do as we evacuate, however, is to help all the Afghanis who helped us and who are now under death threat from the Taliban. But our record on Afghan refugees is shameful. At right from Daniel Bier is a chart of Afghan refugees resettled in the United States–604 last year 494 this year (data here). There are more Afghan immigrants accepted under other programs (not just the refugee program) and we have made motions to accept more but it may now be too late.
Canada in contrast is accepting 20,000 refugees.
Canada plans to resettle more than 20,000 vulnerable Afghans including women leaders, human rights workers and reporters to protect them from Taliban reprisals, Immigration Minister Marco Mendicino said on Friday.
The effort is in addition to an earlier initiative to welcome thousands of Afghans who worked for the Canadian government, such as interpreters, embassy workers and their families, he told a news conference.
“As the Taliban continues to take over more of Afghanistan, many more Afghans’ lives are under increasing threat,” he said. He did not provide a timetable.
Defense Minister Harjit Sajjan said some Canadian special forces were in Afghanistan taking part in the relocation effort but gave no details.
“The challenges on the ground are quite immense,” he said.
A Step Closer to General AI
From Google’s Deep Mind:
In recent years, artificial intelligence agents have succeeded in a range of complex game environments. For instance, AlphaZero beat world-champion programs in chess, shogi, and Go after starting out with knowing no more than the basic rules of how to play. Through reinforcement learning (RL), this single system learnt by playing round after round of games through a repetitive process of trial and error. But AlphaZero still trained separately on each game — unable to simply learn another game or task without repeating the RL process from scratch.
…Today, we published “Open-Ended Learning Leads to Generally Capable Agents,” a preprint detailing our first steps to train an agent capable of playing many different games without needing human interaction data. We created a vast game environment we call XLand, which includes many multiplayer games within consistent, human-relatable 3D worlds. This environment makes it possible to formulate new learning algorithms, which dynamically control how an agent trains and the games on which it trains. The agent’s capabilities improve iteratively as a response to the challenges that arise in training, with the learning process continually refining the training tasks so the agent never stops learning. The result is an agent with the ability to succeed at a wide spectrum of tasks — from simple object-finding problems to complex games like hide and seek and capture the flag, which were not encountered during training. We find the agent exhibits general, heuristic behaviours such as experimentation, behaviours that are widely applicable to many tasks rather than specialised to an individual task. This new approach marks an important step toward creating more general agents with the flexibility to adapt rapidly within constantly changing environments. (Bold added, AT).
Hat tip: at Less Wrong who notes “This seems like a somewhat big deal to me. It’s what I would have predicted, but that’s scary, given my timelines.” See also the LW comments.
In other news, South Africa awarded the first ever patent to an AI.
Excess Deaths in India
Abhishek Anand, Justin Sandefur, and Arvind Subramanian calculate excess mortality in India since April 2020 based on three different datasets (each with their own challenges.) Each estimate indicates that excess mortality is more likely around 4 million than the official figure of 400,000. These figures accord with what everyone on the ground has been telling me. Nearly all my Indian friends report deaths among their family or friends.
…the most critical take-away is that regardless of source and estimate, actual deaths during the Covid pandemic are likely to have been an order of magnitude greater than the official count. True deaths are likely to be in the several millions not hundreds of thousands, making this arguably India’s worst human tragedy since partition and independence.
Photo Credit: REUTERS/ADNAN ABIDI
Bullshit Ability as an Honest Signal of Intelligence
By Martin Harry Turpin, et.al.:
Navigating social systems efficiently is critical to our species. Humans appear endowed with a cognitive system that has formed to meet the unique challenges that emerge for highly social species. Bullshitting, communication characterised by an intent to be convincing or impressive without concern for truth, is ubiquitous within human societies. Across two studies (N = 1,017), we assess participants’ ability to produce satisfying and seemingly accurate bullshit as an honest signal of their intelligence. We find that bullshit ability is associated with an individual’s intelligence and individuals capable of producing more satisfying bullshit are judged by second-hand observers to be more intelligent. We interpret these results as adding evidence for intelligence being geared towards the navigation of social systems. The ability to produce satisfying bullshit may serve to assist individuals in negotiating their social world, both as an energetically efficient strategy for impressing others and as an honest signal of intelligence.
Here is the full article. Am I allowed to call him the “straight-shooting Kevin Lewis“?
How to extract information from on-line reviews, or why Star Wars is still a thing
Online reviews promise to provide people with immediate access to the wisdom of the crowds. Yet, half of all reviews on Amazon and Yelp provide the most positive rating possible, despite human behaviour being substantially more varied in nature. We term the challenge of discerning success within this sea of positive ratings the ‘positivity problem’. Positivity, however, is only one facet of individuals’ opinions. We propose that one solution to the positivity problem lies with the emotionality of people’s opinions. Using computational linguistics, we predict the box office revenue of nearly 2,400 movies, sales of 1.6 million books, new brand followers across two years of Super Bowl commercials, and real-world reservations at over 1,000 restaurants. Whereas star ratings are an unreliable predictor of success, emotionality from the very same reviews offers a consistent diagnostic signal. More emotional language was associated with more subsequent success.
Here is more from Matthew D. Rocklage, Derek D. Rucker, and Loran F. Nordgren, via the excellent Kevin Lewis.
New issue of Econ Journal Watch
Volume 18, Issue 1, March 2021
In this issue (.pdf):
Will you live longer if you move to a place where people live longer? Commenting on an American Economic Review article, Robert Kaestner examines the causality behind an association between Medicare enrollees’ longevity and their post-Katrina migration from New Orleans to various destinations. Tatyana Deryugina and David Molitor reply to Kaestner.
Does machine learning improve corporate fraud detection? Commenting on a Journal of Accounting Research article, Stephen Walker investigates the findings for the effectiveness of machine learning in detecting accounting fraud. Yang Bao, Bin Ke, Bin Li, Y. Julia Yu, and Jie Zhang reply to Walker.
Is institutional quality impacted by immigration from poor or corrupt countries? Garett Jones and Ryan Fraser suggest overcontrol bias in works studying the issue, propose to investigate the matter using simpler evidence, and find indications of adverse impact on economic freedom. Jamie Bologna Pavlik, Estefania Lujan Padilla, and Benjamin Powell controvert the suggestion of overcontrol bias and provide new results finding against any such adverse impact.
Adam Smith in Love: Enrique Guerra-Pujol considers several pieces of evidence and concludes that Adam Smith very likely knew from personal experience what it meant to be in love with another person.
A final inning on colonial money: Ronald Michener has persistently challenged the scholarship of Farley Grubb on colonial money. Here, Professor Grubb replies to Michener’s last rejoinder, focused again on the experience of colonial New Jersey.
Against Standard Deviation as a Quality Control Maxim in Anthropometry: Austin Sandler discusses a pervasive practice in his field of anthropometry: Rejecting data sets in which standard deviations are ‘too big.’ He describes the origin and spread of this practice and its rationales, and argues against it.
Readworthy 2050: We complete the fielding of the question: What 21st-century works will merit a close reading in 2050? New responses are provided by Mitchell Langbert, Andrés Marroquín, Steven G. Medema, Alberto Mingardi, Paul D. Mueller, Stephen R. Munzer, Evan W. Osborne, Justin T. Pickett, Rupert Read and Frank M. Scavelli, Hugh Rockoff, Kurt Schuler, Daniel J. Schwekendiek, Per Skedinger, E. Frank Stephenson, Scott Sumner, Cass R. Sunstein, Slaviša Tasić, Clifford F. Thies, and Richard E. Wagner. (The first tranche is here.)
The History of Economic Thought as a Refined Liberal Art: Kevin Quinn reflects on intellectual history as a way of cultivating our humanity, with compliments for Don Lavoie.
EJW Audio:
Enrique Guerra-Pujol on Adam Smith’s Love Life
Lucas Berlanza on Liberalism in Brazil
Scott Drylie on Scholarship on Adam Smith on Schooling and Government
Call for papers:
Commentaries on Smith/Hume scholarship
Who should get the Nobel Prize in economics, and why?
EJW invites ‘journal watch’ submissions beyond Econ.
EJW fosters open exchange. We welcome proposals and submissions of diverse viewpoints.
Read the March 2021 issue in full (.pdf)
The rude people who comment on Derek Lowe’s blog
Gotta love the logic of bioethicists…
>> Hey guys, can we maybe run a vaccine challenge trial to help accelerate research? We’ve got 30k volunteers signed up already
Aw jeez, that would be horrible! Humans are unable to consent to taking a deadly risk! (though lets ignore doctors volunteering to work despite PPE shortages or soldiers volunteering to fight in remote countries) We might harm a few hundred people with this challenge trial so its best if we just run a Phase 3 trial and wait for months and months to get the results. Who cares if lives could be saved by accelerating the research?
>> Hey guys, we’ve got this vaccine candidate that’s only effective on young people. Can we just launch a Phase 3 trial for young people while we run a separate Phase 1/2 trial for older people?
Aw jeez, that would be bad! Old people are people too and we might hurt someone’s feelings if we declare that there’s a vaccine that’s only available for young folks. Lets just delay it by many months instead to the point where it becomes irrelevant, even if it could’ve saved tens of thousands of people in the meantime.
>> Folks, I’ve got this Oxford vaccine that’s 62% effective and has no major side effects. Can we start using it?
Aw jeez, absolutely not! Some people might get offended because they could’ve received the 90% effective vaccine instead, even if that 90% vaccine is in short supply and wouldn’t actually be available to them for many months to come. Rather than offending people, we should just let them die from COVID – that way we’re not to blame for anything. So lock that vaccine up until you run many more trials and ignore the fact that this causes tens of thousands of extra deaths. Bio ethics above all!
Here is the post link. From myst_05.
How to Vaccinate and Continue Clinical Trials
According to Helen Branswell writing at STAT:
There are serious signs the Food and Drug Administration is getting cold feet over the notion of issuing emergency use authorizations to allow for the widespread early deployment of Covid-19 vaccines.
…“We are concerned about the risk that use of a vaccine under an EUA would interfere with long-term assessment of safety and efficacy in ongoing trials and potentially even jeopardize product approval,” Gruber said. “And not only the first vaccine, but maybe even follow-on vaccines.”
This is nonsense. There are many ways to conduct clinical trials while releasing a vaccine—indeed, we can make the clinical trials better by randomizing a phased release. Suppose we decide health care and transit workers should be vaccinated first. No problem–offer the workers the vaccine, put the SSNs of those who wants the vaccine into a hat like draft numbers, vaccine a randomly chosen sub-sample, monitor everyone.This is the well known lottery technique for measuring causal effects often used in the school choice literature. If we use this technique we can greatly increase sample sizes and as we study each wave we will gather more confidence in the data. We won’t have enough vaccine in November to vaccinate everyone or probably even all health care and transit workers so a lottery is an ethically fair as well as statistically useful way to distributed the vaccine. We can also randomize across cities and regions.
Tyrone, never one to mince words, also has good suggestions:
First, they could simply pay people to partake in those trials. Isn’t that in essence what the NBA did with its Covid testing in the bubble? If the value of those clinical trials truly is so high, it should be possible to internalize enough of those benefits to encourage participation. If institutional barriers stand in the way there, let’s obsess over fixing those.
Why should we force so many Americans to be sacrificial lambs, just to subsidize the trial costs? Let those costs be taken out of grant overhead! (And admin. salaries, if need be.)
…Second, there is another way to keep the trial up and running. Approve use of the treatment, but allow the suppliers to charge very high prices! Better yet, use the law to make them charge high prices and if need be forbid insurance coverage.
Or we could use human challenge trials. The ethical objections to such are now looking more and more like nonsense as thousands of people die weekly.
In short, the idea that releasing a vaccine in phases is a threat to clinical trials is a dangerous and false dichotomy and another example of how our leaders lack vision, imagination, and courage.
The Distribution of Vaccines in the 19th Century
Distributing a COVID vaccine to billions of people will be challenging. We will require vials, needles, cold storage, air travel, trained health care professionals and much more. The challenge of distributing a smallpox vaccine in the 19th century was even greater because aside from fewer resources the vaccine, cowpox, was geographically rare and infected humans only with difficulty. Moreover, the best method of storing the vaccine was in a person but that worked only until the person’s immune system defeated the virus. Thus, a relay-race of vaccine couriers was created to distribute the vaccine around the world.
In 1803, the [Spanish] king, convinced of the benefits of the vaccine, ordered his personal physician Francis Xavier de Balmis, to deliver it to the Spanish dominions in North and South America. To maintain the vaccine in an available state during the voyage, the physician recruited 22 young boys who had never had cowpox or smallpox before, aged three to nine years, from the orphanages of Spain. During the trip across the Atlantic, de Balmis vaccinated the orphans in a living chain. Two children were vaccinated immediately before departure, and when cowpox pustules had appeared on their arms, material from these lesions was used to vaccinate two more children.
The British tried the same thing to get the vaccine to India but heat and shipwrecks led to many failures until, as Andrea Rusnock writes, Jean De Carro successfully delivered live cowpox to Bombay from Vienna via Baghdad.
De Carro, a Genevan who had received his M.D. from Edinburgh and who practiced medicine in Vienna, became one of the staunchest supporters of Jenner on the continent. It was through De Carro’s effort that vaccination was introduced in Austria, Poland, Greece, and the cities of Venice and Constantinople. In a letter to Jenner, De Carro carefully described his successful shipping technique. First he saturated lint with cowpox lymph and then placed the lint between two pieces of glass, one concave, one flat. He then sealed it with oil. “To prevent the access of light,” De Carro continued, “I commonly fold it in a black paper, and when I was desired to send to Baghdad, I took the precaution of going to a wax-chandler’s, and surrounded the sealed-up glasses with so much wax as to make balls. With this careful manner it arrived still fluid on the banks of the Tigris.
In the United States, Thomas Jefferson also wanted to be vaccinated but after several failures to deliver live cowpox from the Harvard Medical School, “Jefferson designed a new container: An inner chamber would hold the fluid lymph, while a surrounding chamber, filled with cool water, insulated the lymph.”
[Later] President Thomas Jefferson gave some cow lymph to Meriwether Lewis and William Clark to take on their explorations west of the Mississippi River. Antoine Saugrain, the only practicing physician in St. Louis when Louisiana was purchased by the United States from France in 1803, received some cowpox lymph from Lewis and Clark and began to vaccinate individuals free of charge, including Native Americans. Saugrain’s free vaccination program established cowpox in the Mississippi valley roughly a decade after Jenner published his inquiry.
Talk about Operation Warp Speed!
Even when delivered, the vaccine had to be kept alive so each cohort of vaccinators was incentivized to provide the vaccine for the next cohort:
In Glasgow, parents had to put down a deposit of 1 shilling (1801) and later 2 shillings (1806) to be refunded only when the child was returned to the clinic [and more cowpox could then be extracted from the children’s lesions]. In Boston, Waterhouse resorted to paying parents to vaccinate their children in order to keep a supply of cowpox.
Occasionally, herd immunity would be reached but that meant there was no way to store the vaccine for the next generation! Physicians, therefore, looked to newly created institutes that shipped the vaccine by one method or another around the world.
Returning to the British and India, after cowpox was delivered through De Carro’s efforts to Baghdad an Armenian child was infected and lymph from his arm was taken to Basra where an East India Company surgeon established a an arm-to-arm relay race that brought cowpox to Bombay:
On 14 June, 1802, Anna Dusthall became the first person in India to be successfully vaccinated against smallpox. Little else is known about her, except that she was “remarkably good tempered”, according to the notes of the doctor who vaccinated her…The following week, five other children in Bombay were vaccinated with pus from Dusthall’s arm. From there, the vaccine travelled, most often arm-to-arm, across India to various British bases – Hyderabad, Cochin, Tellicherry, Chingleput, Madras and eventually, to the royal court of Mysore.
As today, there was fear and opposition to the vaccine, especially in India, because it was foreign, threatened local healers who used variolation, and the use of vaccine couriers meant that “the vaccine was passing through bodies of all races, religions, castes and genders, and that ran counter to unyielding Hindu notions of purity.”
To counter the opposition, the British started an advertising campaign featuring Indian royalty. The picture above, for example, according to one compelling interpretation shows three Indian queens of Mysore with the queen on the right prominently portraying her arm where she has been inoculated with cowpox while the older queen on the left shows the discoloration around the mouth associated with smallpox. Thus, the younger queen on the right symbolizes health, vigor and the value of British science.
The challenges of delivering a vaccine in the 19th century–storage, transportation, fear, and incentives–are surprisingly similar to the challenges we face today. The 19th century effort to deliver the smallpox vaccine was impressive. Within years of Jenner’s pamphlet, the vaccine had made its way around the world. The 21st century effort will need to be much larger. Our civilization has many more resources than that of the 19th century. I hope we can match their will and ingenuity.
From Christianity to liberalism
Daniel Klein sets the record straight:
Olsson: But was it Christianity in particular, or monotheism more generally, that opened up the road to liberalism? Don’t other religious traditions and civilizations also have ideas on individuals, moral agency, and the conscience?
Klein: Monotheism is necessary but not sufficient. Other monotheistic religions didn’t have moral agency, moral equality, and the conscience in quite the same way. Siedentop says that Christianity was quite exceptional in the dignity it accorded the individual. That individual was a votary of the Christ with responsibility to figure out how to advance the well-being of the widest whole of humankind.
Siedentop speaks a lot about moral equality, and I think that one aspect of what he means is that everyone, no matter how depraved or religiously misguided, even an enemy, has the potential for upward vitality, and everyone, no matter how saintly and accomplished up to the present moment, has the potential for downward moral movement. Each of us faces a same sort of moral challenge all the time. Siedentop would associate this image of the individual with Augustine. The implication is that everyone is with or potentially with God, and as an individual. It isn’t about abiding by a set of ritualistic practices. It is a very individual affair.
Siedentop argues that liberalism emerged from, and best prevails today, in what was once thought of as Christendom. If you look at a map of economic freedom today, you will see that the “most free” countries generally correlate to Christendom circa 1300, plus areas (North America, Australia and New Zealand, arguably Japan) that have since been developed by or influenced by the Christian West. In a sense his book is a theory of that correlation, an explanation. Christianity made liberalism possible—which is not say that, within a country, Christianity is sufficient for, or will necessarily produce, liberalism.
Here is the full interview, recommended. And here is a related tweet.