The ethics and economics of randomized trials — a bleg

In late October I'm supposed to talk on this topic at the National Institutes of Health.  It's not so much a lecture (this is not my area) as me offering some introductory remarks — from the perspective of an outsider — and then serving as discussion leader.

What should I read?  Do you have any particular points to offer on this topic?  I (and the NIH) thank you in advance for the assistance.