Here is one sample point:
First, that the Enlightenment project of Reason to which many transhumanists are committed is self-erosive and requires nonrational validation. Transhumanist advocates for Bayesianism and transcending cognitive biases need to confront the repeated implosions of the religion of Reason into romanticism and mysticism, and develop more sophisticated and nuanced defenses of rationality.
…while most transhumanists are liberal democrats, their Enlightenment beliefs in human perfectibility and governance by reason can also validate technocratic authoritarianism. Even staunchly libertarian transhumanists appear to be blithely unaware that arguments for government by benign superintelligent beings that know human interests better than we do recapitulate arguments for totalitarianism from the French Revolution through Marxist-Leninism.