Injectable NanoParticles Let Mice See Near InfraRed!

Wow! This paper, Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantenna, newly published in Cell seems like something from the future. Basically they injected nano-particles that convert near infra-red to visible light into the retinal layer of the eye in mice enabling the mice to see in the near infra-red.

…we developed ocular injectable photoreceptor-binding upconversion nanoparticles (pbUCNPs). These nanoparticles anchored on retinal photoreceptors as miniature NIR light transducers to create NIR light image vision with negligible side effects. Based on single-photoreceptor recordings, electroretinograms, cortical recordings, and visual behavioral tests, we demonstrated that mice with these nanoantennae could not only perceive NIR light, but also see NIR light patterns. Excitingly, the injected mice were also able to differentiate sophisticated NIR shape patterns. Moreover, the NIR light pattern vision was ambient-daylight compatible and existed in parallel with native daylight vision. This new method will provide unmatched opportunities for a wide variety of emerging bio-integrated nanodevice designs and applications.

…In summary, these nanoparticles not only provide the potential for close integration within the human body to extend the visual spectrum, but also open new opportunities to explore a wide variety of animal vision-related behaviors. Furthermore, they exhibit considerable potential with respect to the development of bio-integrated nanodevices in civilian encryption, security, military operations, and human-machine interfaces, which require NIR light image detection that goes beyond the normal functions of mammals, including human beings. Moreover, in addition to visual ability enhancement, this nanodevice can serve as an integrated and light-controlled system in medicine, which could be useful in the repair of visual function as well as in drug delivery for ocular diseases.

The researchers are mostly from China. It sometimes seems that Chinese researchers are naturally extropian, bolder and more optimistic about technology, human extension and the future than anyone else in the world.

Hat tip: Paul Kedrosky.


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