Category: Medicine
No Pain Relief for Tort Sufferers
James Hamilton takes a look at one of the key studies on Vioxx and heart attacks. He is not greatly impressed.
I took a look at one of the studies on which the decision was
justified, written by Dr. David Graham and co-authors and published in Lancet
in February. This study looked at 8,143 Kaiser Permanente patients who
had suffered a heart attack and had also at some point taken a
nonsteroidal anti-inflammatory drug (NSAID), of which Vioxx (rofecoxib)
is one. Of these patients, 68 were taking rofecoxib while 4,658 were
receiving no medication at the time of their heart attack, a ratio of
(68/4658) = 1.46%. For comparison, the study looked at 31,496 other
patients who had also at some point taken an NSAID, matched for
characteristics like age and gender with the first group, but who
didn’t have a heart attack. The ratio of rofecoxib users to those with
no current medication was slightly lower (1.05%) in this second group,
which one might summarize as a (1.46/1.05) = 1.39-fold increase risk of
heart attack from taking rofecoxib compared to no NSAID. Is that
statistically significant, in other words, can you rule out that you’d
see a difference of that size just by chance? Yes, the study claimed,
but just barely.On the other hand, this was not a controlled experiment, in which
you give the rofecoxib randomly to some patients and not others in
order to see what happens. Rather, something about either these
patients or their doctors led some of them to be using rofecoxib and
others not. Dr. Graham and co-authors looked at a variety of indicators
that suggested that the rofecoxib patients already had slightly
elevated risk factors for coronary heart disease. Once they controlled
for these with a logistic regression, their study found an elevated
risk factor of heart attack for rofecoxib takers of 1.34, which was not
statistically significantly distinguishable from 1.0.The strongest evidence from this study was a claimed dose-effect
relation. Of these 68 rofecoxib-using heart-attack patients, 10 of them
were taking doses above 25 mg per day. Only 8 patients in the much
larger control group were taking so high a dose, implying an elevated
risk factor of 5 to 1 for high-dose patients. Again observable risk
factors could explain some of this, with the conditional logistic
regression analysis bringing the implied drug-induced risk down to 3 to
1. According to the study, this elevated risk factor was still
statistically significant, even though the inference is based on the
experience of just 10 patients.The obvious question here is whether in fact the authors were able
to observe all the relevant risk factors. The study openly acknowledged
that it did not, missing such important information as smoking and
family history of myocardial infarction.…[E]ven if
there actually is an elevated risk of the magnitude the studies suggest
but can’t prove, the question is whether I might want to accept a 1 in 4,000 risk of dying from a heart attack in order to get the only medication timt makes my pain bearable and a mobile life livable. And if I say no to the Vioxx, I may end up taking something that is less effective for my pain but has risks of its own.…. How did we arrive at a
system in which 12 random Texans are assigned responsibility for
evaluating the scientific merits of statistical evidence of this type,
weighing the costs and benefits, and potentially sending a productive blue-chip American company into bankruptcy protection?
See also my op-ed Bringing the Consumer Revolution to the FDA.
The fear of death
Robin Hanson writes:
Humans clearly have trouble thinking about death. This trouble is often invoked to explain behavior like delays in writing wills or buying life insurance, or interest in odd medical and religious beliefs. But the problem is far worse than most people imagine. Fear of death makes us spend fifteen percent of our wealth on medicine, from which we get little or no health benefit, while we neglect things like exercise, which offer large health benefits.
Here is the (short) paper. Here is another paper on the same topic, here is Robin’s interpretative take on the authors:
When the salience of death is increased, such as by standing next to a Mortuary, we tend to want to reward heros more and punish prostitutes more. We tend to favor more those who praise our religion and nation and those who criticize others. We become more reluctant to disrespect items like flags or crucifixes. We think we are better drivers, and that others agree with us more. We try harder to divert attention from our less popular features and group identifications. We believe more in the supernatural. People with high self-esteem are mostly immune to these effects.
My take: Bryan Caplan and I have an ongoing debate. He holds the traditional economist’s view that people are usually more rational with more important or more decisive choices. I see important exceptions to this principle. Many critical choices cause people to freeze up, become more dogmatic, distract their attention, or engage in greater self-deception. But I am not as skeptical as Robin is about the benefits of health care expenditures.
Addendum: Try this NBER paper on denial of death.
Just how bad is U.S. health care?
Malcolm Gladwell delivers a lengthy polemic. He favors some form of national health insurance, but is this the correct conclusion? A few observations:
1. He is correct that "too much insurance" is not the problem. Health savings accounts are not the answer.
2. Many of the current uninsured are linked to immigration, or voluntarily uninsured. This is not pure institutional failure.
3. Gladwell downplays moral hazard, arguing that the fully insured wealthy do not forgo their golf games for superfluous doctor visits. But the real problem comes from the other side: doctors overbill or perform unnecessary procedures.
4. The U.S. health care system probably is the world’s best for some class of people, namely the well-off and I don’t mean just the super-rich. Trying to extend those benefits — however this might be accomplished — is a better approach than nationalizing the sector.
5. Much of our excess spending is to make people feel they have done everything they can for themselves or their relatives. It is partly voluntary in nature. Socialized systems don’t allow many of these options to reach the menu in the first place. We need to think long and hard about the right answer here; it is not useful to simply call these expenditures wasteful.
6. The whole debate is emphatically not about "a few simple questions," as Gladwell suggests at the end.
7. No one has a good plan for socializing American medical care or insurance.
8. Much European health comes from diet, walking, and tighter social networks of friends. Don’t expect European healthcare policies to produce the same level of well-being in the United States.
Thanks to Mark LaRochelle for the pointer.
Modern Germs
Guns, Germs, and Steel emphasized the role that germs played in the clash of civilizations of the early modern period, say up to about 1700. I was surprised to learn from John M. Barry’s excellent book The Great Influenza that germs continued to have a disproprtionate influence on the civilizations well into the twentieth century and perhaps even today.
The great influenza of 1918 probably killed 100 million people, about five percent of the entire world’s population. An even higher percentage of young people died and most shockingly all of this occured in about 12 weeks. Death was not evenly distributed:
The Western world suffered the least, not because its medicine was so advanced but because urbanization had exposed its population to influenza viruses so immune systems were not naked to it. In the United States, roughly 0.65 percent of the total population died, with roughly double that percentage of young adults killed. Of developed countries, Italy suffered the worst, losing approximately 1 percent of its total population….
The virus simply ravaged the less developed world. In Mexico the most conservative estimate of the death toll was 2.3 percent of the entire population, and other reasonable estimates put the death toll over 4 percent. That means between 5 and 9 percent of all young adults died.
In even more remote areas the death toll was much higher. One doctor visiting Inuit in Alaska found everyone dead in 3 villages and 7 other villages with a death toll of 85%. We don’t know how many people died in India and China but the rates were certainly higher than in the more urban United States.
By the way, an enterprising researcher should be able to make use of the 1918 influenza in Mexico (and elsewhere as well) as a shock to population that likely had important reverbations throughout the economy and society for decades.
Addendum: Bill Johnson at UVA points me to, Is the 1918 Influenza Pandemic Over? (NBER), a very recent paper by Douglas Almond. From the abstract:
In the 1960-1980 Decennial U.S. Census data, cohorts in utero during the height of the Pandemic typically display reduced educational attainment, increased rates of physical disability, lower income, lower socioeconomic status, as well as accelerated adult mortality compared with other birth cohorts. In addition, persons born in states with more severe exposure to the Pandemic experienced worse outcomes than those born in states with less severe Pandemic exposures. These results demonstrate that investments aimed at improving fetal health can have substantial long-term effects on subsequent health and economic outcomes.
Now consider, if the effects in the United States are large then in Mexico, not to mention India and China (where data will be much harder to gather), the effects could have been devastating on a macro scale.
Avian flu update
No good news here:
1. Human cases appear to be developing in Kazhakstan.
2. There is probably (weak) human-to-human transmission in Indonesia.
3. Birds are spreading the flu to other birds in Europe, and probably later to Australia and North America as well.
4. Casualties continue in Vietnam.
5. The Chinese government is not being forthright about the possibility — admittedly speculative — of rampant bird flu (for birds and humans) on its territory.
6. Bird flu is now entrenched in bird populations throughout Southeast Asia for at least the next six to eight years, giving the virus more time to mutate and possibly become a pandemic.
Your chance of dying from avian flu is much greater than your chance of dying from terrorism. Yet the Bush Administration is still doing virtually nothing.
For documentation, and further updates, check in regularly on avianflu.typepad.com, the avian flu blog which I run with Silviu Dochia.
Addendum: Do not get too hopeful about recent vaccine reports.
Medicare at work
…[there are] striking variations in what Medicare pays for care in different states, or even neighboring Zip codes. In 2001, the typical Medicare patient in Los Angeles cost the government $3,152 more than a comparable patient in the District. A patient in Miami cost $3,615 more than one in Baltimore.
Those disparities cannot be explained by differences in local prices or rates of illness, said John E. Wennberg, a Dartmouth physician and an expert on geographical variations in medical care. Rather, higher spending is related to the number of specialists, hospital beds and technology available. "If you have twice as many docs in a community," said Wennberg, "you end up with twice as many office visits."
Yet most high-spending states rank near the bottom in quality of care, Medicare data show. Louisiana ranked 50th in quality yet first in Medicare spending in 2001, the most recent year available. New Hampshire was first in quality but 47th in spending.
Andrew Samwick has more, including the original links.
We shall see how many funerals…
Let us take out of the Hospitals, out of the Camps, or from elsewhere, 200, or 500 poor People, that have Fevers, Pleurisies, etc. Let us divide them in Halfes, let us cast lots, that one half of them may fall to my share and the other to yours; I will cure them without bloodletting and sensible evacuation; but do you do as ye know (for neither do I tye you up to the boasting, or of Phlebotomy, or the abstinence from a solutive Medicine) we shall see how many Funerals both of us shall have: But let the reward of the contention or wager, be 300 Florens, deposited on both sides: Here your business is decided.
That was Jean Baptiste van Helmont in the 17th century. It took three hundred years for randomized trials to become widespread in the medical profession. Now the MIT Poverty Action Lab, among others, is advocating their use in evaluating the effectiveness of development projects (and other policy interventions). Since many projects are rolled out gradually, rolling them out with some randomization generates very good data without much extra effort required.
Medicare Incentives
A superb article on Medicare from the WashPost nailed a key problem:
In Medicare’s upside-down reimbursement system, hospitals and doctors
who order unnecessary tests, provide poor care or even injure patients
often receive higher payments than those who provide efficient,
high-quality medicine.
Read the whole thing, data, graphs, and good analysis, here.
Do airplanes make weird people stick out less?
When you live in a small village, or hunter-gatherer society, everyone knows that a weird person is weird. You stick out like a sore thumb. But when I fly to, say, Dubai, hardly anyone knows I am weird. Perhaps I dress differently, talk differently, and spend too much time reading books, but to them I appear weird in any case. The proverbial "Aunt Millie from Peoria" also would come across as strange. The differences in weirdness are blurred, and the truly weird can pass for simply being "foreign."
I recall my time in Yemen: all the women wore veils, and all the men carried daggers and chewed qat. Just don’t ask me who the weirdos were.
This suggests that airplanes lower the costs of being weird. Of course, with enough globalization — especially mass market images — this relationship can cut the other way. Perhaps the people in Dubai are wondering why I don’t act more like Tom Cruise. Alternatively, we might send them some more Johnny Depp movies.
Does this mean that weird men are more likely to have foreign wives?
Rx for OTC
I went to the doctor yesterday. I told him that to avoid altitude sickness in Peru I wanted a prescription for Diamox. He used to be surprised when I self-diagnosed but he knows me now. He wrote the prescription and I was done in less than four minutes. I like my doctor but this visit took an hour of my time and probably cost the insurance company at least $100, my deductible was $25. No big deal for me but a non-trivial expense for someone without insurance.
Why aren’t more pharmaceuticals available over the counter? In other words, why must we pay the priestly caste known as physicians for the right to treat ourselves? "Safety," we are told (second only to "for the children" as an excuse for giving up liberty). But, as Sam Peltzman pointed out long ago, safety runs both ways. Not getting a pharmaceutical because it’s too expensive and time consuming to go through a doctor has adverse safety consequences and there is no evidence that the costs of potential mistreatment outweigh the costs of undertreatment. (In anycase, politics not safety is often the reason for restrictions on OTC drugs e.g. the morning after pill.)
In fact, there are many countries where prescriptions are not required for legal medicines and they appear to do just fine. Writing in Reason, Kerry Howley points out (online version, the print version is longer and I am quoted) that in this respect if no other Myanmar is a bastion of rationality and liberty compared to the United States.
Last year, while living in the Southeast Asian nation of Myanmar,
my phones were tapped, my journals were read, my work was censored, and
for the first time in my life, I was given the authority to care for my
own body.There is no prescription drug system in Myanmar, but there are plenty of illnesses waiting to befall an effete Western immune system. My expatriate colleagues and I were free to treat our ailments as we saw fit.
We staved off food poisoning and bouts of malaria with frequent trips to
the local pharmacy, consulting doctors when necessary, but ultimately
responsible for our own medical decisions. We formed doctor-patient
relationships that were partnerships rather than paternalistic
hierarchies, and each of us lived to tell the story.Coming back to the States in the midst of hand-wringing about direct-to-consumer advertising, the restriction of life-saving cholesterol drugs, a wrenching process to make the morning-after-pill readily available, and now a push to put Sudafed behind the counter, it’s increasingly hard to understand why Americans cede crucial health decisions to the bureaucratic dithering of the FDA. In an age of empowerment through information, it is mind-boggling that patients are still willing to be silent spectators while their doctors call the shots.
Department of Uh-Oh (another continuing series)
The Medicare drug prescription benefit is in trouble:
Crucial information, like the monthly premiums and the names of covered drugs, will not be available until mid-September. After hearing federal officials praise the program for about 45 minutes, Joan M. Jenness, 72, of Bridgton, Me., said: "I heard nothing I had not heard before. I still have lots of questions."
Everyone enrolled in Medicare is eligible for prescription drug coverage. But public opinion polls suggest that many people have not heard about the new benefit or do not understand it, and many have not decided whether to sign up for it.
The economics of the new program depend on the assumption that large numbers of relatively healthy people will enroll and pay premiums, to help defray the costs of those with high drug expenses. Insurers say the new program cannot survive if the only people who sign up are heavy users of prescription drugs.
Here is the full story. I am willing to buy the notion that prescription drugs do people more good than most other forms of medical care. So a Medicare program, for a given level of expenditures, should not penalize drug expenditures. But the benefit plan we are getting is surely one of the most ill-conceived pieces of legislation in modern times.
Can placebo effects cure your allergies?
People itching for a solution to seasonal allergies could get help from self-hypnosis, a team of Swiss researchers suggests. The study finds that simply focusing one’s thoughts on allergen-free environments can reduce symptoms of hay fever by one-third.
Beware my posts on the sciences; I like to report results which confirm my priors. Here is the full story.
Voltaire: Game Theorist
Voltaire didn’t just champion markets he used them to his advantage. In one scheme he successfully cornered the market on a poorly-designed government lottery buying all the tickets to score a sure profit. Jerry Muller writing in his excellent The Mind and the Market: Capitalism in Western Thought speculates that Voltaire’s legendary hypochondria also had an economic basis.
Voltaire loaned large sums of money to members of the royalty, in return for a lifelong annual payment…He lived for eight-four years, and throughout the last four decades of his life, he spoke of illness and his imminent demise. Since his debtors had to make the full annual payments only as long as the original lender was alive, those to whom Voltaire loaned funds were more likely to agree to a higher annual rate if they had reason to think that his life would be short.
Intelligence predicts health and longevity
Large epidemiological studies of almost an entire population in Scotland have found that intelligence (as measured by an IQ-type test) in childhood predicts substantial differences in adult morbidity and mortality, including deaths from cancers and cardiovascular diseases. These differences remain significant after controlling for socioeconomic variables.
Here is the full article, courtesy of Randall Parker. It suggests another perspective on why health care appears not to contribute to health. Gross health care expenditures — an input — are not always the best way to measure real health care outputs. (Similarly, gross educational expenditures do not much predict learning, once we adjust for other factors.) High IQ is correlated with compliance with doctors’ instructions, good choice of doctor, adequate medical attention, and so on. High IQ thus appears to be doing some of the work that should be credited to health care, as properly defined and measured.
Policy implications: Targeting gross expenditures on health is not the best approach to making people healthy. But this does not mean that health is neutral with respect to health care policies. A smart policy can make people much better off, just as smart patients live longer.
My next question: Do veterinarians extend the lives of the animals they care for?
Why health care is good for you
Here are the bald asseverations I made to Bryan Caplan yesterday, over Bolivian food:
1. Health care is very, very good for you. Here is one good summary of the earlier blogosphere debate.
2. Don’t be fooled by studies that say the opposite.
3. At most those studies show that health care is not good for you at some additional margin. Make sure you get to that margin.
4. It is true that many regressions show a zero positive effect for health care once you introduce a variable for income. This mainly shows that income is a better proxy for real health care than many of our highly imperfect measures for health care.
5. Almost every family in my Mexican village has lost a kid or two before the kid reaches age five. Few of these deaths would have occurred if a) a doctor rather than a shaman were around, b) they had a ready antidote for scorpion bites, c) they knew to take the right pills for diarrhea and fever and to stay hydrated. These variables will be more closely correlated with measured income than with whatever screwy figure the Mexican government provides for expenditures on medical care. Health care still matters, even though it won’t show up as significant in the regression.
6. The above example can be generalized to wealthier countries. Might education be the best proxy of all for the consumption of real health care? Yes stupid doctors can kill you but a smart patient will not do better staying at home.
7. It is obvious that health care leads to greater longevity, and this is the greatest good of all. Just ask yourself, how much money would you have to receive to give up health care for the rest of your life? For me no sum of money would suffice.
8. Yes the famous Rand Corporation study showed that more doctor visits don’t help people. I can buy that, but advances in medical science still bring huge pay-offs.
Caveats: These are lunchtime comments, I am not accountable for them in the same way as if I posted them on my blog. And I am still too afraid to go see the doctor and get a check-up.