A new Operation Warp Speed for better vaccines
The Biden administration is launching a $5 billion-plus program to accelerate development of new coronavirus vaccines and treatments, seeking to better protect against a still-mutating virus, as well as other coronaviruses that might threaten us in the future.
“Project Next Gen” — the long-anticipated follow-up to “Operation Warp Speed,” the Trump-era program that sped coronavirus vaccines to patients in 2020 — would take a similar approach to partnering with private-sector companies to expedite development of vaccines and therapies. Scientists, public heath experts and politicians have called for the initiative, warning that existing therapies have steadily lost their effectiveness and that new ones are needed…
Jha and others said the new effort will focus on three goals: creating long-lasting monoclonal antibodies, after an evolving virus rendered many current treatments ineffective; accelerating development of vaccines that produce mucosal immunity, which is thought to reduce transmission and infection risks; and speeding efforts to develop pan-coronavirus vaccines to guard against new SARS-CoV-2 variants, as well as other coronaviruses.
Here is the WaPo article, here is commentary from Eric Topol.
Monday assorted links
1. Benevolent sexism. And should single American women look for suitors abroad?
2. Does summer learning loss replicate? And on Covid learning loss recovery: “On average, we find that 20% of test score losses are recovered in English language arts (ELA) by 2022, compared to 37% in math.”
3. Balenciega beige unicorn sneakers. And, via Yana, MEN’S TRASH BAG LARGE POUCH IN BLACK.
4. Does Ozempic improve impulse control? (speculative)
5. No adverse labor supply effects from the expanded child tax credit (short-term only, though).
6. “Apparently, tsunami survivors were inclined to assume greater financial risk in the short-term while rebuilding their lives after the disaster.” Link here.
The case for nurse practitioners
Many states have recently changed their scope of practice laws and granted full practice authority to nurse practitioners, allowing them to practice without oversight from physicians. Physician groups have argued against this change, citing patient safety concerns. In this paper, we use a ratio-in-ratio approach to evaluate whether the transition to full practice authority results in harm to patients as proxied by rates of malpractice payouts and adverse action reports against nurse practitioners. We find no evidence of such harm, and instead find that physicians may benefit from the law change in terms of reduced malpractice payouts against them.
That is from a new NBER working paper by Sara Markowitz and Andrew J.D. Smith.
Science is proceeding
In a few days, a £1.4bn probe will be blasted into space on an eight-year mission to find signs of life on other worlds in our solar system. The spacecraft will not head to local destinations such as the planet Mars, however. Instead, it will fly into deep space and survey the icy moons of distant Jupiter. In doing so, it will open up a new chapter in the hunt for extraterrestrial life.
The Jupiter Icy Moons Explorer – or Juice – will exploit an unexpected feature of our solar system. The greatest reserves of water turn out to exist on worlds very far from Earth, in deep space, and in orbit around the giant planets Jupiter and Saturn. Juice is the first mission to be launched specifically to explore these remote worlds.
Here is the full story, via mdschultz.
Where is the best place to live if a cataclysm comes?
My counterintuitive answer is northern Virginia, or at least the general DC area, putting LDS options aside. I’m talking about asteroids, super-volcanos, and nuclear exchanges, not AGI risk. Here is a Bloomberg column on that topic:
I have a counterintuitive answer: If you live in a dense urban area, stay put — especially if, like me, you live in the suburbs of Washington, D.C.
The biggest advantage of the Washington region is that, in the case of a real catastrophe, it would receive a lot of direct aid. It’s not just that Congress and the White House are nearby — so are the Pentagon, the FBI, the CIA and hundreds if not thousands of government agencies. Insofar as there might be an emergency response to a cataclysmic event, the Washington area will be prioritized.
The region also has plenty of hospitals and doctors, and a wide variety of law-enforcement units — including the various federal agencies as well as police from Maryland, Virginia and D.C. If you care about order being restored, Washington will be better than most places.
Of course, a counterargument is that Washington is more likely than most places to be hit by a cataclysmic event, especially if it involves a nuclear exchange or some other weapon of mass destruction. But there’s “good news,” scare-quotes intended: If a foreign enemy is truly intent on targeting America’s capital, the conflict may be so extreme that it won’t matter where you go. (If I were a foreign power attacking the US, Washington would not be my first choice as a target, as it would virtually guarantee the complete destruction of my own country.)
I consider — and reject — New Zealand and the American West as alternate options. New Zealand might not even let you in.
Saudi fact of the day
In line with its ambitions to diversify its economy away from oil and to become a video gaming powerhouse, Saudi Arabia will be investing $38 billion in the local online gaming industry in Riyadh.
According to a report by Bloomberg on Monday, Savvy Gaming Group, a subsidiary of the kingdom’s sovereign Public Investment Fund (PIF), is seeking not only game projects to acquire, but also to develop and publish its own.
Here is the full story. Remember all those stories years ago, about how Saudi stability was at its end and the Kingdom soon would be bankrupt? Or maybe taken over by terrorists? It seems they were wrong.
Via Anecdotal.
Sunday assorted links
2. Ezra Klein on AI (NYT). And should we use AI to write fortune cookies? (WSJ) Hilarious.
3. “Second, why did duelers use relatively inaccurate weapons when deadlier weapons were available?” [TC: I think I know why.]
4. Interviewing Bryan Caplan on AI.
5. Brendan McCord personal reading list.
6. Losing a mother.
Some doubts about Chinese industrial policy
Each year governments worldwide spend an enormous amount of money subsidising businesses. This column investigates the relationship between the allocation of government subsidies and total productivity for Chinese listed firms. The authors find little evidence that the Chinese government consistently ‘picks winners’. Firms’ ex-ante productivity is negatively correlated with subsidies received by firms, and subsidies appear to have a negative impact on firms’ ex-post productivity growth.
And this:
Our sample includes all firms listed on the Shanghai and Shenzhen stock exchanges from 2007 to 2018 except financial services firms, for which computation of productivity presents a number of challenges.
That is from a new study by Lee Branstetter, Guangwei Li, and Mengjia Ren. Such estimations are typically fraught with questionable assumptions, but at the very least the results do not come up positive.
EA, AI, and the rationality community
More broadly, I think AI Alignment ideas/the EA community/the rationality community played a pretty substantial role in the founding of the three leading AGI labs (Deepmind, OpenAI, Anthropic), and man, I sure would feel better about a world where none of these would exist, though I also feel quite uncertain here. But it does sure feel like we had a quite large counterfactual effect on AI timelines.
That is from “habryka, Ben Pace” on LessWrong blog. As you might expect, I would give those comments a different valence, nonetheless they are insightful. Here are my points:
1. It is truly remarkable how much influence the cited movements have had. Whether or not you agree in full (or at all), this should be recognized and respected. Kudos to them! And remember, so often ideas lie behind technology.
2. Anthropic has announced a raise of $5 billion and is promoting its intention to compete with Open AI and indeed outdo them. The concept “Solve for the equilibrium” should rise in status.
3. You cannot separate “interest in funding AI safety” (which I am all for) from “AI progress.” That by now should be obvious. No progress, no real interest in safety issues.
4. To this day, the Doomsters are de facto the greatest accelerationists. Have you noticed how the Democrats (or Republicans) “own” certain political issues? For instance, voters trust the Democrats more with Social Security, and the mere mention of the topic helps them, even if a Republican has a good point to make. Well, the national security establishment “owns” the ideas of existential risk and risk from foreign powers. The more you talk about doomsday issues, the more AI risk gets slotted into their purview, for better or worse. And they ain’t Brussels (thank goodness). To the extent the Doomsters have impact, their net effect will be to place the national security types in charge, or at least to raise their influence. And how do they think that is going to work out (on their own terms)? Perhaps they would do better to focus on mundane copyright and libel issues with LLMs, but that is not their nature.
Anchorage bleg
Your suggestions are most welcome….Danke!
Saturday assorted links
1. Mary Lou Williams appreciation (NYT).
2. Is D.C. becoming a bagel city?
3. Arthur Allshire on whether LLMs will be an anti-censorship tool.
4. Filipinos nailed to crosses on Good Friday despite objection by Catholic Church.
6. “Pretty incredible that the Indian government has released a version of @OpenAI Whisper fine tuned on a Hindi data set.” And AI and religion is a match made in heaven (NYT). Really. “The flood of papal imagery has been so voluminous that some people in online generative A.I. forums have begged for creators to use another inspiration.” I really like this one.
If you would like to publicize your on-line writings…
No matter in which venue they may appear, including S., please do note that comments are open…
Lessons from the Baruch Plan for Nuclear Weapons
The invention of atomic energy posed a novel global challenge: could the technology be controlled to avoid destructive uses and an existentially dangerous arms race while permitting the broad sharing of its benefits? From 1944 onwards, scientists, policymakers, and other technical specialists began to confront this challenge and explored policy options for dealing with the impact of nuclear technology. We focus on the years 1944 to 1951 and review this period for lessons for the governance of powerful technologies, and find the following: Radical schemes for international control can get broad support when confronted by existentially dangerous technologies, but this support can be tenuous and cynical. Secrecy is likely to play an important, and perhaps harmful, role. The public sphere may be an important source of influence, both in general and in particular in favor of cooperation, but also one that is manipulable and poorly informed. Technical experts may play a critical role, but need to be politically savvy. Overall, policymaking may look more like “muddling through” than clear-eyed grand strategy. Cooperation may be risky, and there may be many obstacles to success.
That is by Waqar Zaidi and Allan Dafoe, at the Centre for Governance of AI, exactly the kind of work people should be doing.
Matt Yglesias on movies vs. TV
But I’ve gotten really disgruntled with the “prestige TV” landscape and am trying to redirect my content consumption accordingly. One thing that makes movies really great in my view is that before they shoot a movie, they write a screenplay and the screenplay has an end. Both the screenwriter and other people have read that screenplay all the way from beginning to end and they’ve tweaked and changed it and gotten it into a position where they are ready to start production. Then after a movie is filmed, the editor and director work with the footage and come up with a complete movie that has a beginning, a middle, and an end. They then ship the movie out, and it’s screened by critics who watch the entire movie before writing their review.
This does not guarantee that every movie that comes out is good. But it does guarantee that if someone tells you “‘The Menu’ is good,” they are evaluating a completed product…
By contrast, TV shows have this quasi-improvisational quality where the showrunners are constantly needing to come up with new balls to toss into the air. In old-fashioned non-prestigious “adventure of the week”-type shows, this actually works fine because the writers are not building up tension or setting unexplored plots in motion. But as serialized TV storytelling has gotten more and more common, we’re more and more often asked to show patience through early episodes or to try to find things intriguing with no ability to know whether any of it will pay off. Creators often have no idea where they’re going with the story.
Back in HBO’s heyday, the tradeoff was that The Sopranos and The Wire got to paint on a giant canvas and tell stories that are just too capacious for the movie format. But eventually networks got tired of spending that kind of money and cut back the sizes of the casts to something more normal for television.
That is from his Friday mailbag ($). The bottom line is that, like Matt, you should watch more movies and less TV.
Did Ottoman Sultans ban print?
Did printing transform the Ottoman Empire? And what took the Ottomans so long to print? Much of the scholarship surrounding the topic of Ottoman printing, or the occurrence of printing within the Ottoman Empire (1453–1922), is structured around these two related frameworks. In this essay, I argue that these frameworks are ahistorical because they predicate Ottoman printing on the European experience of print. To support this point, I examine the disproportionate role played by certain early modern European accounts of Ottoman printing within Western and Arabic historiography. In particular, I examine the life cycle of scholars’ belief that Ottoman sultans banned printing, which I contrast with extant documentation for the imperial Porte’s stance on printing. I argue that the sources available to scholars today do not support the notion that the sultans banned printing. Rather, they demonstrate that this claim arose from early modern European scholars’ search to articulate their sense of Ottoman inadequacy through explanations for why Ottomans did not print. The history of this particular line of inquiry is significant, I argue, because many scholars continue to probe the issue of why Ottomans did not print. In so doing, they maintain the expectation that print would revolutionize society, even though they have begun questioning the existence of the ban.
That is from Kathryn A. Schwartz, in Print History (jstor). Via Benedikt A.