Spain’s second wave of Covid-19
Did this happen? Were Spain’s hardest hit provinces in the spring spared in the second wave?
To get a quick sense of the answers to those questions I plotted the cumulative number of cases per 100,000 population in the Spanish provinces since June 15 against the proportion of the population in the provinces that tested positive for antibodies after the first wave. If herd immunity were playing a large role in suppressing cases in the second wave, we would expect to see a negative relationship between provinces with high levels of antibodies in the population at the end of May and total case counts since that time…
Instead of a negative correlation, there is a positive, although weak, correlation between having higher prevalence of antibodies in the population and having a higher case rate in the second wave.
…Take Madrid for example, if roughly 13% of the population had antibodies after the first wave, at least one of the low-HIT models estimates the Rₑ would be approximately 60% lower than than the unmitigated reproductive rate (R₀). If population immunity were reducing transmission in the Madrid area by 60% below unmitigated levels, it seems unlikely Madrid would again have one of the highest rates of infection in the second wave [yet it does].
…Ultimately, the strongest conclusion that can be drawn from this look at infection rates is that there is not clear evidence herd immunity is playing a significant role, yet.
Also take a look at a deeper dive looking for herd immunity in Sweden (spoiler alert: no signs of it yet).
It is fine to call this inconclusive, but still the pattern predicted by standard herd immunity claims is not yet showing up. Here is the whole piece from Kbenes, very useful.
And elsewhere, this was not supposed to happen, as New York Orthodox Jews also have been cited as a “herd immunity” community:
Officials this week released statistics showing that the positivity rate in some Orthodox Jewish neighborhoods [in NYC] had grown to anywhere from 3 percent to 6 percent, significantly more than the city’s overall rate of between 1 percent and 2 percent. Officials are especially worried about the positivity rates in the Brooklyn neighborhoods of Borough Park, Midwood and Gravesend, which they have referred to as the “Ocean Parkway Cluster.”
Here is that full story (NYT).
Jimmy Butler markets in everything
You’ve heard of Bubble Tea? Well, this is Bubble Coffee:
In a recent interview with ESPN’s Rachel Nichols, Butler said coffee was hard to find on the NBA’s Orlando campus. He and his French press are keeping his teammates caffeinated, one extremely overpriced cup at a time.
“You can’t get coffee nowhere here,” [Jimmy] Butler said in the interview. “So I might bump it up to 30 bucks a cup. People here can afford it.”
…According to the menu outside his Walt Disney World hotel room, Butler’s offerings include a latte, a cappuccino, a macchiato and more. A small cup goes for the hefty price tag of $20. (A medium and large go for the same price, so you might as well spring for the venti.)
Here is the full ESPN story, via Christina.
Friday assorted links
Australian price discrimination
The cheapest deal, at $6.99, was offered to queer females aged under 30. City-based straight men over 50 were meanwhile given the most expensive rate, at $34.37. Choice investigators could not find a pattern to explain the differences, and have appealed to Australia’s consumer watchdog, the ACCC, to investigate whether Tinder might be in breach of national consumer law.
Here is the full story, via an MR reader.
A Vitamin D Bet
It was always odd to me that hydroxychloroquine became a shibboleth. Vitamin D seemed like a better focal point (cheap, safe, natural!) and the case for its effectiveness is not without merit. Indeed, an Israeli company, RootClaim, which combines crowdfunding of data with Bayesian algorithms to improve decision making (yeah, some reasons for skepticism here) has offered to bet anyone $100,000 (I think at 1:1 odds) that Vitamin D works against COVID. The precise bet is as follows:
Rootclaim is willing to bet $100,000 that vitamin D is effective in reducing the severity of Covid-19.
Our claim: By April 1st, 2022, it will be accepted by health professionals that a vitamin D treatment protocol similar to that used in the study is better than existing treatments (remdesivir and corticosteroids) in reducing the odds of severe outcomes, which we will define as a minimum 1.5x reduction in odds of admission to the ICU.
- The challenger needs to show that they can commit $100,000. We are open to discussing lower or higher amounts, and the funds can be pooled from multiple sources.
- Both sides will agree in advance on the specifics of how a winner is determined, and what arbitration mechanism to use, if need be.
- The challenger needs to declare that they do not have access to any relevant non-public information. This is to protect from abuse in case of unpublished research (there is still a small chance that further research will discover the treatment is ineffective). For the same reason, we may update these terms or withdraw the offer, as new information emerges.
Rootclaim is putting a lot of weight on their analysis of this study. Evaluate at your own risk but I have been taking Vitamin D and trying to get some extra sun since the beginning of the pandemic.
Hat tip: Gordon Shotwell who has a useful overview of Vitamin D research and COVID here.
European paintings show a rise in trustworthiness
Building on recent advances in social cognition, we design an algorithm to automatically generate trustworthiness evaluations for the facial action units (smile, eye brows, etc.) of European portraits in large historical databases. Our results show that trustworthiness in portraits increased over the period 1500–2000 paralleling the decline of interpersonal violence and the rise of democratic values observed in Western Europe. Further analyses suggest that this rise of trustworthiness displays is associated with increased living standards.
That is from a new paper by Lou Safra, et.al. in Nature. Scroll down a few pages for some good photos, basically the people in the paintings look less pissed off over time. Via Lionel Page.
Crypto art markets in everything
Christie’s is set to sell its first nonfungible token in an upcoming auction of what has been characterized as “the largest artwork” in the history of Bitcoin (BTC).
Art historian turned blockchain artist Robert Alice has created “Portrait of a Mind” — a monumental series of 40 paintings stretching over 50 meters in length.
Drawing on the history of 20th century conceptualism as well as the founding myth of Bitcoin’s creation, “Portrait of a Mind” is a complete hand-painted transcription of the 12.3 million digits of the code that launched the cryptocurrency.
By scattering the codebase into 40 globally distributed fragments, the project will “draw up a global network of 40 collectors where no one individual will hold all the code,” Alice said.
He explained: “In each work, an algorithm has found a set of hex digits that together are highlighted in gold. These read a set of coordinates that are unique to each painting. 40 locations across 40 paintings – each location is of particular significance to the history of Bitcoin.”
Speaking to Cointelegraph, Alice said he remains curious as to why much of the commemoration of Bitcoin emphasizes the publication of the whitepaper over and above the codebase itself, which, for him, is “the real historical document.”
Christie’s will sell one painting from the series, “Block 21 (42.36433° N, -71.26189° E),” as part of its “Post-War and Contemporary Day Auction” on Oct. 7, at the end of a week-long exhibition of auctioned works in New York.
The piece includes a unique fungible token as an integral part of the work and will be offered at an estimated price of $12–18,000.
Here is the full story, via Shaffin Shariff.
Solve for the Seattle equilibrium
Seattle now has on its payroll a convicted pimp who once vowed to “go to war” with the city — a $150,000 “street czar” whose mission is to come up with “alternatives to policing,” reports said.
Andre Taylor — who appeared in the documentary “American Pimp” about his life as “Gorgeous Dre” — is getting $12,500 per month for a year, along with an office in Seattle’s Municipal Tower, according to the contract published by PubliCola.
It comes just a year after his organization, Not This Time, was paid $100,000 to sponsor a speaker series that was called “Conversations with the Streets.”
Here is the full story, which has further points of interest, via JK.
Thursday assorted links
1. Claims about how to cook the perfect dosa.
2. The Supreme Court will not wreck Obamacare.
3. Some guy something to do with golf something or other something.
4. New survey on pre-existing immunity. And yet some additional results.
5. NYT on cases vs. deaths in Europe. And the FT on the Finnish success. And FT on the Madrid second wave, and a contrast with NYC. Doesn’t settle the key issues, but a good overview.
Challenge Trials in Britain!
London is to host the world’s first Covid-19 human challenge trials — in which healthy volunteers are deliberately infected with coronavirus to assess the effectiveness of experimental vaccines. The UK government-funded studies are expected to begin in January at a secure quarantine facility in east London, according to several people involved in the project, which will be announced next week.
…The project’s academic leader is Imperial College London, and it will be run by hVivo, a spinout from Queen Mary University of London that was bought earlier this year by Open Orphan, a Dublin-based pharmaceutical research organisation.
…The petition organiser of 1Day Sooner in the UK is 18-year-old Alastair Fraser-Urquhart who is devoting his time to the campaign before going to University College London to study cancer biology next year.
All hail Alastair Fraser-Urquhart!
This part enraged me:
The NIH is also investigating the technical and ethical requirements for challenge trials. But Nadine Rouphael, a leading vaccine researcher at Emory University in Atlanta and one of several scientists who are keen to carry out challenge studies in the US, said: “There is no urgency at NIH. The UK is well ahead — and that’s great.”
No urgency!!! I raised challenge trials with the administration in April.
Addendum: Previous MR posts on challenge trials. And here is the UK petition and the Canadian petition from 1daysooner.
The COVID Storyline
Do you have good intuition for the time path of per capita (million) deaths from COVID in different countries? Try this Storyline to test yourself. When you are done, Our World in Data has all the data in a single graph.
The game theory of SCOTUS nominations
Despite the conventional wisdom that Trump would surely nominate a judge to secure a conservative majority that would ultimately overturn Roe v. Wade, getting that judge successfully confirmed would diminish Trump’s reelection prospects (by energizing the Democratic base to vote for leaders who would pack the court or ratify PR and DC as states). But Trump doesn’t care a whit about abortion, much less ideology. He only cares about his power and his reelection. His incentive, it seems to me, is to choose a weak nominee who will surely fail confirmation or a nominee whose confirmation will be deferred post-election. If the nomination is rejected, the Democrats will be seen as obstructionists and the Republican base will be energized. A deferred confirmation, in contrast, will act as a carrot that Trump can dangle in front of congressional Republicans, who will more strongly campaign for him. In either case, an unsuccessful confirmation will work in Trump’s favor, while a confirmed conservative will act against his reelection interests. Such a maneuver by the Trump campaign can, of course, only happen surreptitiously, because it would anger both Democratic and Republican leadership to be manipulated this way.
That is from Shiran Pasternak in my email.
Wednesday assorted links
1. Russian billionaire wants to buy cancelled Confederate statues.
3. Where are the missing right-wing firms? And Arnold.
6. An evidence-based return to work plan.
7. The nasal spray, which will be entering clinical trials.
My Conversation with Alex Ross
Here is the video, audio, and transcript. Of course Alex has a new book out Wagnerism: Art and Politics in the Shadow of Music, which explores the complicated legacy of Wagner and music more generally. We learn Alex’s nomination for the greatest pop album ever made, but many of my questions focused on progress in music and musical performance, the nature of talent, the power of culture, and also cancel culture, Wagner of course having been a frequent target for a long time. Here is one excerpt:
COWEN: One theme of your book, as I understand it, is that Wagnerism historically is more diverse than many people realize. There was a branch of Zionism that loved Wagner. There’s an African American tradition that’s quite interested in Wagner. Maybe you can talk me out of some of the worries I have when I listen to Wagner. When I listen, I feel better if I’m listening to Von Klemperer, who is Jewish, and he was a refugee, and he left Europe to come to America. I feel I’m offsetting something in Wagner that disturbs me.
And if you think about what Wagner has become, it seems the problematic element in Wagner — it does somehow match up to the music in a way which is hard to escape. No one listens to Wagner and comes away saying, “Well dull, bourgeois life, as you find under democratic capitalism, is underrated.” No one comes away from Wagner saying, “I now have a greater appreciation for methodological individualism.” Right?
ROSS: [laughs] No.
COWEN: There’s something ominous about the music. How should we, as listeners, come to terms with that? Should we feel guilty when listening to Wagner, given the association with anti-Semitism, Nazis, and much more?
ROSS: I think you should always be wary, let’s say, to Wagner. My whole history with Wagner was, actually, I started out really averse to the entire sound world. When I was a kid growing up with classical music, I tried listening to Lohengrin. I checked records of Lohengrin out of the public library, and I put them on, and I only could stand it for 10 minutes or so.
Of course, I knew nothing about anti-Semitism and Nazism and the connection with Hitler. It was just purely a question of the sound. I found the sound disturbing and this seasick feeling of bobbing from one chord to another without clear demarcations. I just had this instinctual revulsion to it…
And:
ROSS: …conducting is so mysterious in terms of what is actually happening between the conductor and the orchestra. There are explicit messages being sent. There’re instructions being given, but there’s also this slightly mystical side to it, where once you get to a figure like Klemperer, or today, Bernard Haitink, who just retired, or Herbert Blomstedt, who is incredibly vital and active in his 90s.
COWEN: Coming back at age 93 in Switzerland.
ROSS: Yeah. Even before they say anything, just the mere fact, when [they] arrive at the podium, there is a level of respect. There is a level of attentiveness and readiness in the orchestra. They don’t have to be won over when Herbert Blomstedt is in front of them. His reputation . . .
Blomstedt — someone like this can just skip all the preliminaries and just go for fine-tuning these points, and everyone plays better because they’re in the presence of this celebrated, legendary older musician. It’s almost as if they don’t even need to do anything anymore. They do, of course. They are working very hard, and Blomstedt is delivering very particular instructions to the orchestra.
But there’s that psychological dimension. The musicians are excited to be having this opportunity, and they think this might be the last time, so they give something more. So that’s the mystery of conducting.
I always think of that anecdote about Furtwängler — I think it was Walter Legge who told this story — watching the orchestra rehearse with a different conductor, and they were playing all right, nothing too inspired. He’s looking straight ahead and looking at the orchestra, and suddenly something changes. Suddenly the playing is electrified, transformed. The conductor seems to have done nothing different. And so, “What is going on? How did that change take place?”
Then he happens to look over his shoulder. Furtwängler is standing by the door, watching. In the few minutes that he’s entered the hall and has been standing at the back, the orchestra noticed him there, and their playing changed completely. So that’s the weird, the slightly occult power that the conductors can have. Just their mere presence transforms the playing.
And I start with this:
COWEN: I have so many questions about Wagner. Let me start with one. Why is it I have the perception that the truly great Wagner recordings come from the 1950s or the 1960s? If I think even of the talk you gave for the New Yorker — well, you talked about Keilberth and Solti and Furtwängler. Those are ancient recordings. Clemens Krauss, that was what, 1953? What has happened to the recording quality of Wagner?
Recommended.
The Great Forgetting: How to Stop Tooth Decay
What if I told you that a cheap, effective and painless method of stopping tooth decay had just been invented! You’d be pretty happy. What if I told you that a cheap, effective and painless method of stopping tooth decay was invented over 100 years ago and has been available in other countries for decades but only now is it starting to be used in the United States as a non-FDA approved, off-label treatment? I hope you would be angry. Well, I did tell you this in 2016 in The FDA Versus the Tooth and now the Washington Post has an update.
Studies show silver diamine fluoride stops decay in 60 to 70 percent of cases with one application. A second application six months later boosts the treatment’s long-term effectiveness to more than 90 percent.
In addition to killing cavity-causing bacteria, the treatment hardens tooth structure, desensitizes the tooth and even stops new cavities from forming. Applying the liquid on the exposed root surfaces of older adults once a year is “a simple, inexpensive, and effective way” to prevent cavities, a 2018 study concluded.
One of the most important benefits of the application on older patients is that the liquid can reach decay that forms under existing dental work such as crowns and bridges, said dental hygienist Michelle Vacha, founder of Community Dental Health, which runs clinics in Colorado Springs and Pueblo, Colo.
Previously, a dentist would have had to remove the crown, drill out the cavity and make a new crown — a traumatic, time-consuming procedure with a typical cost of $1,000 or more, Vacha said. Unable to afford the cost, many patients would instead have the tooth pulled.
The paint-on liquid is significantly cheaper than traditional treatment. Estimates vary, but a private dentist may charge $10 to $75 for one application, compared with $150 to $200 for a filling. Hygienists often have lower fees. At Vacha’s community clinics, the cost is $10 a tooth.
…Silver diamine fluoride has been used in other countries for decades, and studies have proved it safe. Its biggest downside is that it permanently turns the decayed area black — a turnoff, in particular, for people with decay on a front tooth. Dental providers say the black spots can be covered by tooth-colored material for an extra cost. For older adults, Geiselhofer said, a dark spot is a small price to pay for a treatment that stops cavities quickly, with no drilling, needle prick or trip to the dentist required.
The FDA deserves some of the blame but incredibly lost science is more common than you might think. You probably know that in 1797 the British Navy required lemon juice on all foreign service to prevent scurvy but did you know that by the early 20th century scurvy had returned because the cure had been forgotten or discounted?
Mental Floss: Yes, this really happened: scurvy was “cured” as early as 1497, when Vasco de Gama’s crew discovered the power of citrus…but this cure was repeatedly lost, forgotten, rediscovered, misconstrued, confused, and just generally messed around with for hundreds of years, despite being a leading killer of seafarers and other explorers. By the 1870s the “citrus cure” was discredited, and for nearly sixty years, scurvy — despite being cured, with scientific research to back it up — continued killing people, including men on Scott’s 1911 expedition to the South Pole. This went on until vitamin C was finally isolated in 1932 during research on guinea pigs.
It’s tempting to think that these forgettings are a product of the past but the more than 100 year loss of silver as a treatment for tooth decay is a painful modern example.
Hat tip: Ari Armstrong and M. Pettengill.